Publications & Presentations

The effects of hypothermia and L-arginine on skeletal muscle function in ischemia-reperfusion injury.

Stahl D, Souder N, Probe R, Sampson W, Tharakan B, Ward R.J Orthop Trauma. 2012 Oct

OBJECTIVES: Ischemia-reperfusion (I/R) injury can have detrimental effects on skeletal muscle. We have shown that vessel permeability can be minimized in a hypothermic setting and also by administering the nitric oxide synthase (NOS) stimulator, L-arginine, at physiologic temperatures. The purpose of this study was to examine and compare skeletal muscle contractility after an I/R insult during hypothermic conditions, warm conditions, and also with the administration of L-arginine at physiologic temperatures. We hypothesized that hypothermia and L-arginine administration will also demonstrate protective effects to skeletal muscle contractility.

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The role of nitric oxide synthase and heme oxygenase in the protective effect of hypothermia in ischemia-reperfusion injury.

Ward R, Souder N, Stahl D, Hunter F, Probe R, Chaput C, Childs E. J Bone Joint Surg Am. 2009 Nov

BACKGROUND: Ischemia-reperfusion injury plays an important role in limb salvage following limb ischemia. The purpose of the present study was to evaluate the effect of local hypothermia and chemical modulators on microvascular permeability following ischemia-reperfusion injury in skeletal muscle.

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